In keeping with liberal arts traditions, Clark's mathematics major provides a solid education in mathematical principles for students who wish to apply mathematics in other fields and students who wish to pursue mathematics in graduate school. Clark mathematics majors have gone on to graduate school in pure mathematics, applied mathematics, and computer science at such universities as Brown, Cornell, Johns Hopkins, and NYU (Courant Institute). Graduates are employed in the public and private sectors as statisticians, mathematical modelers, and actuaries, as well as teachers from the elementary to university level.

The mathematics major, built around a core of fundamental courses, is best started early with Calculus (Math 120-121 or Math 124-125); in the first year. Advanced electives provide some flexibility and allow students to tailor the major to their needs. Following the description of the requirements are suggestions for concentrations in pure mathematics, applied mathematics, and actuarial science.

Department faculty are eager to help students select courses. If a major has not been declared earlier, it must be declared by the end of the sophomore year. Students should choose an academic advisor from the department faculty as early as possible, and in any case by the end of the sophomore year. (Entering students enrolled in First-Year Seminars in programs outside mathematics, computer science, or the natural sciences are especially encouraged to make a prompt choice of an unofficial secondary advisor in the Mathematics Department, who will be able to supplement the advice offered by their primary advisor.)

For students interested in potential careers in mathematics, the Mathematical Association of America publishes a career brochure, entitled We Do Math!, which "describe a variety of non-academic careers for which a background in the mathematical sciences is useful."